Clinical pathological analysis of uterine leiomyomas in 487 cases

Objective:To study the age-related incidence,location,histological classification,complication,and pathogenesis of uterine leiomymas.Methods:Histological classification according to WHO new classification method was performed with the uterine biopsy and pathological study.Results:The age-related incidence was 40-50 year old mostly.The masses were seen intra-smooth muscle mostly,but sub-serosa and sub-mucus membrane rarely.There were three classes:leiomyomas in 479 cases(97%),sarcoma in 2 cases(1%),and uncertain potential malignancy in 5 cases(2%).The complication included overproliferation of uterine intima,adenomyoma,ovarian cyst,uterine intima polup,ovarian hydrops,teratoma,and granular cell neoplasm.Conclusions:These complications confirms that the pathogenesis of uterine leiomyomas is associated with the elevation of estrogen level.