Defensive mechanism of increasing expression of coonexin43 for neurons in cerebral astrocyte of rats with andiogenic seizure

Objective To observe the alteration of the expression of Cx43in cerebral astrocyte caused by audiogenic seizure.Method Genetic epilepsy prone rat P77PMC was used as a model and immunohistochemical method was applied to detect the time-co urse alteration of Cx43ex-pression in P77PMC rat ' s cerebral astrocyte.Result After audiogenic seizure,Cx43expression was detected in cerebral cortex and hippocampus and appeared time-dependent increa sing.Conclusion Astrocytes in cerebral cortex and hi ppocampus might be activated by audi ogenic seizure,which might be beneficial to keep the stability of neuron' s peripheral environment and thus protect the neurons.