Effect of monosialotetrahexosylganglioside on reducing the increased intracranial pressure in the patients with acute severe traumatic brain injury

Objective To study the effect of monosialotetrahexosylganglioside(GM1) on reducing the increased intracranial pressure(ICP) and alleviating the brain edema in the patients with acute severe traumatic brain injury(sTBI).Methods 44 patients with sTBI were divided into observation group(n =22) and control group(n = 22) randomly.Incision of trachea,mild hypothermia treatment and bone-flap remove surgery were done in the two groups.The conventional treatments such as ehydration,anti-infection drug,retrieving the balance of water electrolyte and nutrition supporting were done in the control group.Based on the conventional treatments,intravenous drip with GM1 saline injection 100 mg was added in observation group,once-daily for 7 days.The changes of ICP at 2 hours,4 hours,6 hours,8 hours,3 days and 7 days were monitored and the brain edema index at 1 day,3 days,5 days and 7 days were observed with noninvasive the cerebral edema monitor before and after treatment in the two groups.The state of the relief of brain edema was evaluated by brain CT scan at 7 days after treatment and the glasgow coma scores(GCS) in two groups were contrasted.Results The ICP at 4 hours after treatment and the brain edema index at 3 days after treatment in GM1 therapy group were lower than those in the control group(P 0.05);At 7 days after treatment brain CT scan indicated that the degree of satisfaction of the relief of brain edema was higher than that in the control group(P 0.05);The GCS scores were higher than those in the control group(P 0.05).Conclusion GM1 can reduce the increased ICP and alleviate the brain edema at early stage of sTBI,and can improve the level of coma in the patients.