Research on Nano-micelles Used as Drug Carriers Based on Thermosensitive Amphiphilic Block Copolymers

The thermosensitive amphiphilic block copolymers have drawn much attention due to their potential applications.In the field of drug controlled-delivering system,the polymeric micelles based on such block copolymers show several preferable unique characteristics when used as drug carriers.Polymeric micelles comprising block copolymers would achieve target sides by passive targeting mechanism.If thermo-responsive segment was introduced into block copolymer,active targeting mechanism would be achieved.The molecular design,synthesis and self-assemble behavior of the block copolymer,as well as the drug loading and release of the polymeric micelles,are summarized in this review.Herein,we focus on recent progress of the thermosensitive amphiphilic block copolymers containing poly(N-isopropylacrylamide) segment.