Clinical significance of pathological examination to patients with chronic hepatitis B having normal or mild abnormal liver transaminases

Objective Analysis of normal and mild abnormal transaminases in patients with chronic liver biopsy results of liver biopsy for instruction in antiviral therapy. Methods 258 patients were examined in serum and liver biopsy specimens.According to the elevated alanine transaminase(ALT),the patients were first divided into normal group(n=78) and abnormal group(n=180),and then againdivided into ALT raise≥twice the upper limit of normal(n=83) and twice the upper limit of normal.Pathological analysis of liver inflammation and injury and fibrosis degree then againdivided into were comparable indicators. Results In those patients with normal liver function,17 cases(21.8%) had inflammation necrosis≥G2,27 cases(34.6%) fibrosis ≥S2.33 cases(42.3%) of liver biopsy in patients with normal liver function proved anti-viral indications,there were 98 cases(56.0%) in ALT 2×upper limit of normal with liver biopsy consistent with anti-viral indications.ALT=63.3 U/L prediction for the critical inflammation and necrosis or fibrosis ≥S2 ≥G2,the area under the curve was 0.781. Conclusion For normal and mild abnormal liver function of chronic hepatitis B patients,liver biopsy should be judged in the liver disease activity and the main basis for antiviral therapy.In case that liver biopsy is unavailable,the suggestion for doctors is ATL≥63.3 U/L as screen indicator for antiviral therapy.