2009•Shandong yiyaoRequires access

Inhibition growth and survivin expression of nasopharyngeal carcinoma cell CNE-1 induced by EGCG

Xun Lei

Abstract

Objective To study the inhibition growth of nasopharyngeal carcinoma cell line CNE-1 and the molecular mechanisms induced by(-)-epigallocatechin-3-gallate(EGCG).Methods The growth inhibition ratio of CNE-1 cell line was observed at different time points treated with different concentrations of EGCG by MTT,the survivin mRNA was measured with RT-PCR.Results After treated with EGCG,The CNE-1 cell's growth inhibition rate were increased,while the expression of survivin mRNA were reduced with dose and time dependent.Conclusions EGCG can significant inhibited nasopharyngeal carcinoma cell line CNE-1's growth,its mechanism is down regulation the expression of survivin mRNA.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Nasopharyngeal carcinoma, Survivin, Cell culture, Growth inhibition, Cell growth, Messenger RNA, Cancer research, Chemistry