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2004•Journal of Baotou University of Iron and Steel TechnologyRequires access

Development of pyrurate dehydrogenase complex

Wang Qi-huan

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Abstract

The structure and functional properties of pyruvate dehydrogenase complex (PDHC) have been reviewed briefly.PDHC is a mitochondrial multienzyme complex including pyruvate dehydrogenase(E_1),dihydrolipoamide acetyltransferase(E_2),dihydrolipoamide dehydrogenase(E_3),pyruvate dehydrogenase,pyruvate dehydrogenase phosphatase,five cofactor and protein X.Pyruvate dehydrogenase complex converts pyruvate to aceryl-CoA that is subatrate for the citric acid cycle.Lactic acidosis can arise from the deficiency of PDHC.

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What this paper is about

The structure and functional properties of pyruvate dehydrogenase complex (PDHC) have been reviewed briefly.PDHC is a mitochondrial multienzyme complex including pyruvate dehydrogenase(E_1),dihydrolipoamide acetyltransferase(E_2),dihydrolipoamide dehydrogenase(E_3),pyruvate dehydrogenase,pyruvate dehydrogenase phosphatase,five cofactor and protein X.Pyruvate dehydrogenase complex converts pyruvate to aceryl-CoA that is subatrate for the citric acid cycle.Lactic acidosis can arise from the deficiency of PDHC.

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Available abstract

The structure and functional properties of pyruvate dehydrogenase complex (PDHC) have been reviewed briefly.PDHC is a mitochondrial multienzyme complex including pyruvate dehydrogenase(E_1),dihydrolipoamide acetyltransferase(E_2),dihydrolipoamide dehydrogenase(E_3),pyruvate dehydrogenase,pyruvate dehydrogenase phosphatase,five cofactor and protein X.Pyruvate dehydrogenase complex converts pyruvate to aceryl-CoA that is subatrate for the citric acid cycle.Lactic acidosis can arise from the deficiency of PDHC.

Key concepts: Pyruvate dehydrogenase complex, Pyruvate dehydrogenase phosphatase, Oxoglutarate dehydrogenase complex, Dihydrolipoyl transacetylase, Pyruvate dehydrogenase kinase, Pyruvate decarboxylation, Branched-chain alpha-keto acid dehydrogenase complex, Citric acid cycle

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