2001•Journal of Radiation Research and Radiation ProcessingRequires access
INFLUENCES OF IONIZING RADIATION ON APOPTOSIS AND CELL CYCLE OF HelaS_3 CELL LINES
Jin Guanghui, MH Radiobiology
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Abstract
Changes of apoptosis and cell cycle progression of HeLaS 3 cells following irradiation with different doses of X rays were observed. The percentages of apoptotic cells were examined by flow cytometry (FCM) after the cells had been stained with propidium iodine(PI) and Hoechst33342(HO), and the cell cycle was detected by FCM stained with only PI. It was found that the percentages of apoptotic cells and the cells in S phase and G 2/M phase increased after irradiation with 0.5-4.0Gy X rays. So irradiation may induce apoptosis and cell cycle block for HelaS 3 cell lines.