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2014•Journal of Oral Science ResearchRequires access

Detection of AXIN2 Gene Mutations in Xinjiang Uyghur Oligodontia Patients

Liu Jia-y

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Abstract

Objective:To explore the mutational sites of AXIN2of Xinjiang Uygur patients with oligodontia of non-syndrome and to provide a molecular basis and genomics reference for the diseases in the population of Uygur. Methods:We collected three Uygur non-syndromic hypodontia family.DNA was extracted from buccal swab samples from family members.The AXIN2gene was amplified with polymerase chain reaction technique and then directly sequenced.Results:3non-syndromic oligodontia Uighur families was inherited in an auto some-dominant manner,patients with a different number of missing teeth or associated with cone-shaped teeth.Sequence results of Axin2showed three SNPs.Conclusion:The results suggest that the three nucleotide change in exon 2and exon 6 in AXIN2gene might associate with oligodontia in Xinjiang Uyghur.

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What this paper is about

Objective:To explore the mutational sites of AXIN2of Xinjiang Uygur patients with oligodontia of non-syndrome and to provide a molecular basis and genomics reference for the diseases in the population of Uygur. Methods:We collected three Uygur non-syndromic hypodontia family.DNA was extracted from buccal swab samples from family members.The AXIN2gene was amplified with polymerase chain reaction technique and then directly sequenced.Results:3non-syndromic oligodontia Uighur families was inherited in an auto some-dominant manner,patients with a different number of missing teeth or associated with cone-shaped teeth.Sequence results of Axin2showed three SNPs.Conclusion:The results suggest that the three nucleotide change in exon 2and exon 6 in AXIN2gene might associate with oligodontia in Xinjiang Uyghur.

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Available abstract

Objective:To explore the mutational sites of AXIN2of Xinjiang Uygur patients with oligodontia of non-syndrome and to provide a molecular basis and genomics reference for the diseases in the population of Uygur. Methods:We collected three Uygur non-syndromic hypodontia family.DNA was extracted from buccal swab samples from family members.The AXIN2gene was amplified with polymerase chain reaction technique and then directly sequenced.Results:3non-syndromic oligodontia Uighur families was inherited in an auto some-dominant manner,patients with a different number of missing teeth or associated with cone-shaped teeth.Sequence results of Axin2showed three SNPs.Conclusion:The results suggest that the three nucleotide change in exon 2and exon 6 in AXIN2gene might associate with oligodontia in Xinjiang Uyghur.

Key concepts: Oligodontia, Hypodontia, AXIN2, Genetics, Single-nucleotide polymorphism, Medicine, Biology, Gene

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