STUDY ON THE RELATIONSHIP BETWEEN KLOTHO GENE POLYMORPHISM AND THE LEVEL OF LOW DENSITY LIPOPROTEIN

[Objective] Klotho gene is associated with human aging.The G-395A,F352V and C370S polymorphism of the human Klotho gene has been reported to be associated with coronary Artery disease.The aim of this study focused on the relationship between those 3 of klotho gene polymorphism and the level of low density lipoprotein-cholesterol.[Methods]The 3 polymorphic G-395A,F352V and C370S sites in Klotho gene were analyzed by real-time PCR using TaqMan probs in patients with different levels of low density lipoprotein.[Results]The allele and genotype frequencies in G395A and F352V were found to relate to different levels of LDL-C(P﹤0.01,χ2 were 82.268 and 21.957,respectively),but no significant differences were found in C370S allele and genotype frequencies among people with different levels of LDL-C(P = 0.813,χ2 = 1.576).[Conclusion]C370S allelic variation in Klotho gene does not contribute to the susceptibility of levels of LDL-C,but G395A and F352V allelic variation can be related to the levels of LDL-C.The polymorphisms of G395A and F352V may act as a predictor for the elevate of LDL-C.