Effects of tamoxifen on endometrial lesions in breast cancer patients

Objective To observe the effects of long-term use of tamoxifen on endometrial lesions in breast cancer patients.Methods This study retrospectively analyzed the post-operative data of 166 breast cancer patients from January,2002 to June,2004.The study group included 102 patients who were positive with estrogen and progestogen receptors,and received tamoxifen treatment.The control group included 64 patients who were negative with estrogen and progestogen receptors,and did not receive tamoxifen treatment.Vaginal B ultrasound was performed periodically in all patients,and hysteroscopy and endometrial pathological biopsy were further performed in the patients with possible endometrial lesions.Results There was a statistically significant difference in the incidence of endometrial lesions between the two group(P0.01),with 41.18%(42/102) in the study group and 12.50%(8/64) in the control group,respectively.Conclusion The long-term use of tamoxifen during post-operative period in breast cancer patients can increase the incidence of endometrial lesions.