ScholarLens Back to search
1995•Zhongguo yaolixue tongbaoRequires access

Immunomodulatory effects of Lentinan

Aihua Zhou, Zhi‐Dong Ge, Jun Liang

Open publisher page 4 citations

Abstract

The immunomodulatory effects of Lentinan (LNT) were studied. The results showed that diminished production of the splenocytes in immunosuppressed mice induced by cyclophosphamide was restored by LNT (0.5,1,2 mg·kg￣(-1)·d￣(-1)×5 d, ip). LNT (1￣125 mg·L￣(-1)) markedly enhanced Con A induced murine splenocyte proliferation and IL-2 production by murine splenocytes. Their concentration effect curves seem to be bell-shaped, suggesting that LNT have a dual immunomodulatory activity in a dose-dependent manner.

About this research paper

What this paper is about

The immunomodulatory effects of Lentinan (LNT) were studied. The results showed that diminished production of the splenocytes in immunosuppressed mice induced by cyclophosphamide was restored by LNT (0.5,1,2 mg·kg￣(-1)·d￣(-1)×5 d, ip). LNT (1￣125 mg·L￣(-1)) markedly enhanced Con A induced murine splenocyte proliferation and IL-2 production by murine splenocytes. Their concentration effect curves seem to be bell-shaped, suggesting that LNT have a dual immunomodulatory activity in a dose-dependent manner.

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The immunomodulatory effects of Lentinan (LNT) were studied. The results showed that diminished production of the splenocytes in immunosuppressed mice induced by cyclophosphamide was restored by LNT (0.5,1,2 mg·kg￣(-1)·d￣(-1)×5 d, ip). LNT (1￣125 mg·L￣(-1)) markedly enhanced Con A induced murine splenocyte proliferation and IL-2 production by murine splenocytes. Their concentration effect curves seem to be bell-shaped, suggesting that LNT have a dual immunomodulatory activity in a dose-dependent manner.

Key concepts: Lentinan, Splenocyte, Cyclophosphamide, Chemistry, Pharmacology, Internal medicine, Biology, Medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Immunomodulatory effects of Lentinan — Research Paper | ScholarLens