Application of sufentanil combined with ropivacaine for obstetric epidural analgesia in the cesarean section patients

Objective To explore the application of sufentanil combined with ropivacaine for obstetric epidural analgesia in the cesarean section patient controlled epidural analgesia ( PCEA) .Methods Ninety cases of cesarean section were randomly divided into three groups with spinal-epidural anesthesia, i.e.group A, group B and group C.There were 30 cases in each group.The patients received 0.2 μg/ml sufentanil combined with 0.125% ropivacaine in group A, 0.4 μg/ml sufentanil combined with 0.125% ropivacaine in group B and 0.6 μg/ml sufentanil combined with 0.125% ropivacaine in group C, respectively.Postoperative PCEA were performed through loading dose (5 ml) + continuous dose (3 ml/h) + PCA dose (1 ml/times).The data were analyzed on the VAS scoring of incision pain,uterine pain in the period of 0～3,3～6,6～12,12～24 h postoperatively and the incidence of adverse reactions such as nausea, vomiting, itching, motor block, lethargy, respiratory depression in the period of 0 ～24 h postoperatively.Results The incision pain VAS score and contraction VAS pain score decreased with sufentanil concentration increasing.The defference between Group B, group C and Group A had statistic significance ( P 0.05).The defference between Group B and group C had not statistic significance ( P 0.05 ).The rate of adverse reactions in the nausea and the incidence of itching increased with sufentanil concentration increasesing.The defference between Group C and group B, Group A had statistic significance (P 0.05).The defference between Group B and group A had not statistic significance ( P 0.05 ) .The incidence rate of vomiting, motor block, lethargy had not statistic significance ( P 0.05 ) among the three group.No respiratory depression happened.Conclusion In the cesarean section PCEA, 0.4 μg/ml sufentanil combined with 0.125% ropivacaine can get better analgesic effect and less side effects.