Effect of Angiotensin II Receptor Antagonist on Expression of ICAM-1 in Renal Cortex of Experimental Diabetic Rats

Objective: To investigate the mechanism of Valsartan in protecting the kidney of streptozotocin-induced diabetic rats.Methods: Sprague-dawley rats were randomly divided into diabetic model treated with Valsartan(10mg·kg-1/d)group(A),diabetic model group(B) and normal control group(C).Plasma glucose,kidney mass/body mass ratio,MAP,serum creatinine,urinary creatinine,24 urinary albumin excretion ratio were measured in the 4th,6th week respectively.ICAM-1 mRNA expression in renal cortinal were measured with RT-PCR in the 6th week.And the kidney sample were observed with light and electron microscope.Mean glomerular transverse sectional area and mean glomerular volume were calculated by analysis system of the image.Results: In both two stages,kidney mass/body mass ratio,Ccr,24 urinary albumin excretion ratio in both diabetic group(B) were higher than that of normal group(C)(P0.01),but they were decreased significantly in A group than that in B group.For the urinary albumin in two stages,there was no difference between A and C group(P0.05).In the 4th and 6th,the MGPA and MGV in group A were significantly smaller than that of B group(P0.01).ICAM-1 mRNA expression were higher in B group than that in A and C group.Conclusion: Valsartan could reduce the expression of ICAM-1 mRNA,it could reduce the level of urinary albumin and could prevent the glomerular sclerosis,so the pathological progress of kidney was delayed in diabetic rats.