The relationship between hhlim and cardiac hypertrophy

Objective To investigate the function of hhlim in cardiac hypertrophy. Methods We established the pressure-overloaded hypertension and swimming- overloaded cardiac hypertrophy models in rats. The expression of hhlim was assayed by RT-PCR and Western blot. Results The LV weight/body weight and blood pressure of experimental group increased obviously compared with those of control group, which suggested that abdominal aorta binding and swimming had made LV pressure-overloaded cardiac hypertrophy. Compared with low-level expression of hhlim in cardiac muscle of controls, the contents of hhlim mRNA and protein increased significantly in experimental group. The expression of hhlim in abdominal aorta binding group increased dramatically than that of the swimming group. Conclusions Although the mechanism of swimming-overloaded cardiac hypertrophy may be different from that of hypertensive hypertrophy, the activation of hhim is participated in the course of cardiac hypertrophy induced by the abdominal aorta binding and swimming.