Correlative study on plasma levels of fibrinogen,D-dimer and prognosis in patients with lung cancer

Objective To explore the relationship between plasma levels of fibrinogen and D-dimer,and the prognosis in patients with lung cancer.Methods The plasma levels of fibrinogen and D-dimer were detected in 60 patients with lung cancer and 20 normal controls.Results The D-dimer and plasma fibrinogen were significantly higher than those of normal controls(P0.05).The plasma levels of fibrinogen and D-dimer in patients with lung cancer were not related to histological classification,the size of the primary tumors or P-TNM stages,and were negatively correlated to the survival.Conclusion The hypercoagulability state exists in the patients with lung cancer.The plasma levels of fibrinogen and D-dimer in the patients with lung cancer are correlated with the prognosis.The anti-coagulability treatment may play an important role in controlling the development and prognosis of lung cancer.