The classification and pharmacological characteristics of proton pump inhibitors

Proton pump inhibitors bind covalently to the gastric H+/K+-ATPase via disulfide bond.Proton pump inhibitors are the most potent anti-secretary agent for gastric acid and they are the first choice of acid-related disorders such as peptic ulcer and gastro-esophageal reflux disease or non-steroidal anti-inflammatory drugs-induced gastrointestinal lesions.Omeprazole is the first proton pump inhibitor marketed in 1988,followed by pantoprazole,lansoprazole,rabeprazole,esomeprazole,revaprazan,ilaprazole and dexlansoprazole.Though these proton pump inhibitors share the core structures of benzimidazole and pyridine,they possess a little bit difference in pharmacokinetics and pharmacodynamics.Pharmacological characteristics of some proton pump inhibitors marketed in China are briefly introduced so as to promote their rational use in clinic.