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2012•Anhui Medical and Pharmaceutical JournalRequires access

Advanced research on intestinal cytochromes P450

Haiming Fang

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Abstract

Cytochrome P450(CYP450s) are the main I phase intestinal metabolic enzyme,up to date,seven isoenzymes including CYP1A1,CYP2C9,CYP2C19,CYP2J2,CYP2D6,CYP3A4 and CYP3A5 have been discovered.Intestinal CYP450s have critical role in drug metabolism and drug-drug interaction,and associate with drug therapeutic and adverse effect.Variances of gene polymorphisms and individuals have an impact on drug metabolism,which lead to differences in clinical efficacy.This article reviewed the advanced research on intestinal CYP.

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What this paper is about

Cytochrome P450(CYP450s) are the main I phase intestinal metabolic enzyme,up to date,seven isoenzymes including CYP1A1,CYP2C9,CYP2C19,CYP2J2,CYP2D6,CYP3A4 and CYP3A5 have been discovered.Intestinal CYP450s have critical role in drug metabolism and drug-drug interaction,and associate with drug therapeutic and adverse effect.Variances of gene polymorphisms and individuals have an impact on drug metabolism,which lead to differences in clinical efficacy.This article reviewed the advanced research on intestinal CYP.

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Available abstract

Cytochrome P450(CYP450s) are the main I phase intestinal metabolic enzyme,up to date,seven isoenzymes including CYP1A1,CYP2C9,CYP2C19,CYP2J2,CYP2D6,CYP3A4 and CYP3A5 have been discovered.Intestinal CYP450s have critical role in drug metabolism and drug-drug interaction,and associate with drug therapeutic and adverse effect.Variances of gene polymorphisms and individuals have an impact on drug metabolism,which lead to differences in clinical efficacy.This article reviewed the advanced research on intestinal CYP.

Key concepts: CYP2C9, CYP3A4, CYP2C19, Cytochrome P450, Drug metabolism, CYP2D6, Drug, Pharmacology

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