2010•Zhiye yu jiankangRequires access

Investigation on Reference Value of ALT and Carrying Rate of HBsAg among

Min Zhang

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Abstract

[Objective]To establish the reference value and reference range of alanine aminotransferase(ALT),and survey the carrying rate of hepatitis B surface antigen (HBsAg )in Xinxiang area.[Methods]Totally 13 886 normal people (aged 6~65) without distinct liver,kidney,heart,muscle and tissue lesions were selected. The ALT activity was measured by speed method which had been validated validity. HBsAg was tested by ELISA. Normal test by frequence distribution was performed on ALT results,and results distinction between genders was examined by t test. Mean value ±1.96s was adopted as reference range,if the result was consistent with normal distribution;if not consistent with normal distribution,2.5%~97.5% percentile was adopted as reference. HBsAg carrier rate was expressed in terms of a percentage.[Results]The frequency distribution of ALT results was not normal distribution. The difference of result between genders was significant (t=8.362,P=0.000). The reference ranges were male 4.9~43.0 U/L,female 5.0~44.3 U/L based on 2.5%~97.5% percentile. HBsAg carrying rate was 6.29%.[Conclusion]The reference range of ALT activity and HBsAg carrying rate is different from those of former report. It is necessary to establish the reference value and reference range of ALT activity.

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[Objective]To establish the reference value and reference range of alanine aminotransferase(ALT),and survey the carrying rate of hepatitis B surface antigen (HBsAg )in Xinxiang area.[Methods]Totally 13 886 normal people (aged 6~65) without distinct liver,kidney,heart,muscle and tissue lesions were selected. The ALT activity was measured by speed method which had been validated validity. HBsAg was tested by ELISA. Normal test by frequence distribution was performed on ALT results,and results distinction between genders was examined by t test. Mean value ±1.96s was adopted as reference range,if the result was consistent with normal distribution;if not consistent with normal distribution,2.5%~97.5% percentile was adopted as reference. HBsAg carrier rate was expressed in terms of a percentage.[Results]The frequency distribution of ALT results was not normal distribution. The difference of result between genders was significant (t=8.362,P=0.000). The reference ranges were male 4.9~43.0 U/L,female 5.0~44.3 U/L based on 2.5%~97.5% percentile. HBsAg carrying rate was 6.29%.[Conclusion]The reference range of ALT activity and HBsAg carrying rate is different from those of former report. It is necessary to establish the reference value and reference range of ALT activity.

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Available abstract

[Objective]To establish the reference value and reference range of alanine aminotransferase(ALT),and survey the carrying rate of hepatitis B surface antigen (HBsAg )in Xinxiang area.[Methods]Totally 13 886 normal people (aged 6~65) without distinct liver,kidney,heart,muscle and tissue lesions were selected. The ALT activity was measured by speed method which had been validated validity. HBsAg was tested by ELISA. Normal test by frequence distribution was performed on ALT results,and results distinction between genders was examined by t test. Mean value ±1.96s was adopted as reference range,if the result was consistent with normal distribution;if not consistent with normal distribution,2.5%~97.5% percentile was adopted as reference. HBsAg carrier rate was expressed in terms of a percentage.[Results]The frequency distribution of ALT results was not normal distribution. The difference of result between genders was significant (t=8.362,P=0.000). The reference ranges were male 4.9~43.0 U/L,female 5.0~44.3 U/L based on 2.5%~97.5% percentile. HBsAg carrying rate was 6.29%.[Conclusion]The reference range of ALT activity and HBsAg carrying rate is different from those of former report. It is necessary to establish the reference value and reference range of ALT activity.

Key concepts: HBsAg, Reference range, Percentile, Reference values, Alanine aminotransferase, Medicine, Gastroenterology, Mathematics

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