Effect of different doses of atorvastatin on high sensitivity C reactive protein in patients with acute coronary syndrome

Objectives To investigate the effect of taking different doses of atorvastatin for two weeks on high sensitivity C reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods A total of 126 patients with coronary artery disease in Panyu Central Hospital from November 2009 to September 2011 were divided into two groups randomly and each group had 63 patients.All of them were given nitroglycerin,isosorbide dinitrate,enteric-coated aspirin,low molecular heparin as general therapy.Small dose group was added atorvastatin 20 mg/d to general therapy,and large dose group was added atorvastatin 40 mg/d to general therapy.Serum concentrations of hs-CRP and blood lipid of the patients were detected and comopared before and after two weeks of treatment.Results Serum concentrations of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol LDL-C and hs-CRP were decreased significantly after two weeks' therapy in the two groups(P0.05).Serum concentrations of TC [(4.42±0.62) mmol/L vs.(4.95±0.67) mmol/L,P0.01],TG [(1.02±0.19) mmol/L vs.(1.13±0.23) mmol/L,P0.01],LDL-C [(2.55±0.46) mmol/L vs.(2.64±0.33) mmol/L,P0.01] and hs-CRP [(9.66±1.48) mg/L vs.(10.59±3.32) mg/L,P0.01] decreased more significantly in large dose group.Conclusions Atorvastatin can significantly inhibit inflammation in ACS and decrease serum concentration of hs-CRP.The Effect can be enhanced with increasing dose of atorvastatin.