A Randomized Double-blind Controlled Clinical Trial of Gatifloxacin Versus Levofloxacin in the Treatment of Acute Bacterial Infections

Aim To evaluate the clinical efficacy and safety of gatifloxacin methanesulfonate in treatment of acute respiratory and urinary system bacterial infections.Methods A randomized double-blind controlled clinical trial was conducted of intravenous gatifloxacin in patients with respiratory tract infections or urinary system infections.Levofloxacin was used as the controlled drug.Dosage:gatifloxacin,400mg,qd.and levofloxacin,200mg,bid.5～14 days.The duration of intravenous injection was not less than two hours for gatifloxacin and one hour for levofloxacin.Results In this trial,20 patients were enrolled in the gatifloxacin group,20 patients in the levofloxacin group.The overal efficacy rate and cure rate in the trial group and control group were 85%,60% and 90%,65%;respectively.The rates of bacterial clearance was 77.8% and 87.5%, respectively.The rates of adverse drug reaction were 5% in two groups.There was no statistically significant difference in the above results between the trial group and the control group(P0.05).Conclusion The clinical efficacy and adverse drug reaction of treatment using gatifloxacin methanesulfonate infusion in respiratory and urinary system infections were similar to those produced by Levofloxacin hydrochloride infusion.