Study on the association between growth pattern of preschool age and insulin resistance in small for gestaional age infants

Objective To explore the relationship between growth pattern from birth to preschool age and insulin resistance. Methods Fasting glucose,insulin,HOMA-IR and HOMA-βvalue in 68 small for gestaional age(SGA)infants and 42 appropriate for gestaional age(AGA)infants at age 3-day and 4-year were studied by aprospective study,and the relations with growth pattern were analyzed in 68 SGA infants. Results SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than AGA infants at age 3-day and 4-year(P0.05).No catch-up growth of weight in SGA infants had significantly higher fasting insulin concentration and HOMA-IR value than catch-up growth of weight in SGA infants(P0.01).There was no significant difference in HOMA-βvalue among each groups(P0.05). Conclusions SGA infants display insulin resistance from birth to preschool age.No catch-up growth of weight in SGA infants have higher insulin resistance.The function ofβ-cell of pancreatic islands has no remarkable change.