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Quantitative detection of AFP mRNA in human HCC, per-HCC tissue and peripheral blood by FQ-PCR

Xing Zhang

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Abstract

Objective To determine the AFP mRNA expression in human HCC, per-HCC tissue and peripheral blood and explore its significance. Methods AFP mRNA was detected by FQ-PCR in samples of human HCC, per-HCC tissue ad peripheral blood from 30 patients with HCC. Results The copies of AFP mRNA in HCC tissue were correlated to tumor differentiation, infiltration or metastasis within the liver and value of serum AFP but not AFP mRNA expression in the samples of peripheral blood. Conclusions The abnormal expression of AFP mRNA is detected by FQ-PCR. The expression might be a valuable marker for judging the tumor differentiation and predicting metastasis and recurrence of HCC.

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What this paper is about

Objective To determine the AFP mRNA expression in human HCC, per-HCC tissue and peripheral blood and explore its significance. Methods AFP mRNA was detected by FQ-PCR in samples of human HCC, per-HCC tissue ad peripheral blood from 30 patients with HCC. Results The copies of AFP mRNA in HCC tissue were correlated to tumor differentiation, infiltration or metastasis within the liver and value of serum AFP but not AFP mRNA expression in the samples of peripheral blood. Conclusions The abnormal expression of AFP mRNA is detected by FQ-PCR. The expression might be a valuable marker for judging the tumor differentiation and predicting metastasis and recurrence of HCC.

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Available abstract

Objective To determine the AFP mRNA expression in human HCC, per-HCC tissue and peripheral blood and explore its significance. Methods AFP mRNA was detected by FQ-PCR in samples of human HCC, per-HCC tissue ad peripheral blood from 30 patients with HCC. Results The copies of AFP mRNA in HCC tissue were correlated to tumor differentiation, infiltration or metastasis within the liver and value of serum AFP but not AFP mRNA expression in the samples of peripheral blood. Conclusions The abnormal expression of AFP mRNA is detected by FQ-PCR. The expression might be a valuable marker for judging the tumor differentiation and predicting metastasis and recurrence of HCC.

Key concepts: Messenger RNA, Hepatocellular carcinoma, Real-time polymerase chain reaction, Peripheral blood, Pathology, Clinical significance, Infiltration (HVAC), Peripheral

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