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2015•Journal of Taishan Medical CollegeRequires access

Role of PARP-2 selective inhibitor in cardiac hypertrophy in neonatal rat cardiomyocytes

Geng Bia

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Abstract

Objective: To explore the effects of PARP-2 on the cardiac hypertrophy in vitro. Methods: The expression of PARP-2was knocked down by using selective inhibitor UPF1069 in neonatal rat cardiomyocytes and the cardiomyocyte hypertrophy was evaluated by measuring the mRNA levels of ANF,BNP,and β-MHC and cell-surface area. Results:In the neonatal rat cardiomyocytes,the expression of PARP-2 knocked down by using selective inhibitor UPF1069,indicating that endogenous PARP-2 played a positive regulatory role in cardiac hypertrophy. Conclusion: Knockdown of PARP-2 protects cardiomyocytes from hypertrophy.

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What this paper is about

Objective: To explore the effects of PARP-2 on the cardiac hypertrophy in vitro. Methods: The expression of PARP-2was knocked down by using selective inhibitor UPF1069 in neonatal rat cardiomyocytes and the cardiomyocyte hypertrophy was evaluated by measuring the mRNA levels of ANF,BNP,and β-MHC and cell-surface area. Results:In the neonatal rat cardiomyocytes,the expression of PARP-2 knocked down by using selective inhibitor UPF1069,indicating that endogenous PARP-2 played a positive regulatory role in cardiac hypertrophy. Conclusion: Knockdown of PARP-2 protects cardiomyocytes from hypertrophy.

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Available abstract

Objective: To explore the effects of PARP-2 on the cardiac hypertrophy in vitro. Methods: The expression of PARP-2was knocked down by using selective inhibitor UPF1069 in neonatal rat cardiomyocytes and the cardiomyocyte hypertrophy was evaluated by measuring the mRNA levels of ANF,BNP,and β-MHC and cell-surface area. Results:In the neonatal rat cardiomyocytes,the expression of PARP-2 knocked down by using selective inhibitor UPF1069,indicating that endogenous PARP-2 played a positive regulatory role in cardiac hypertrophy. Conclusion: Knockdown of PARP-2 protects cardiomyocytes from hypertrophy.

Key concepts: Gene knockdown, Poly ADP ribose polymerase, Muscle hypertrophy, Endogeny, PARP inhibitor, Myocyte, Internal medicine, Endocrinology

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