Study on Angiogenesis of Epithelial Ovarian Neoplasms

Objective To explore the angiogensis in epithelial ovarian neoplasms and the relationship among angiogenesis and clinical stage, the histological type and pathological grade of epithelial ovarian carcinomas. Methods The microvessel density (MVD) was examined in 74 cases of epithelial ovarian neoplasm and 20 nomal samples by using immunohistochemical SP method. Results MVD increased gradually from benign to borderline malignancy and ovarian carcinomas, and MVD there was a significant difference in between the borderline malignancies and benign tumors or normal tissues(P0 05). But there was no siginificant differences in MVD between the ovarian carcinomas and borderline malignancies or benign tumors and normal samples(P=0 34 and P=0 46,respectively). Log rank test showed that no correlation was found between MVD and survival rate (Log-rank P=0 27). Conclusions Angiogensis may play an important role in pathogenesis and development of ovarian cancer, and MVD can be used as an index to estimate the malignant degree of ovarian neoplasms. MVD could not serve as an index to predict the prognosis of patients with epithelial ovarian cancer.