Protective effect of p38MAPK inhibitor on acute lung injury in rats with severe acute pancreatitis

Objective To explore the protective effect of p38MAPK inhibitor on acute lung injury in rats with severe acute pancreatitis. Methods A random number table method,60 rats were divided into three groups,group A was sham operation group,B group for severe acute pancreatitis model group,C group,severe acute pancreatitis model and p38MAPK inhibitor group; rat lung,pulmonary pathology and rats lung wet to dry weight ratio,pulp peroxide enzyme activity and p38MAPK mRNA expression level of three groups were detected. Results The rats in B group compared with A group of rats,the pathological lung injury score,lung wet to dry weight ratio,lung tissue myeloperoxidase( MPO) activity and the expression level of p38MAPK mRNA in lung tissue were significantly increased,while the rats of group C the above indexes were compared with the B group rats decreased,P 0. 05. Conclusion p38MAPK inhibitors can reduce the release of TNF-α,reduce inflammation,for the clinical treatment of severe acute pancreatitis complicated with acute lung injury and provide a new direction.