2005•Journal of Zhengzhou UniversityRequires access
Changes of ultrastructures of neurons in nucleus accumbens, hippocampal CA1 of chronic morphine treated rats
Zhang Rui-ling
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Abstract
Aim: To explore the changes of ultrastructures of neurons in nucleus accumbens (NAc), hippocampal CA1 (HIPCA1) of chronic morphine-treated rats.Methods: Ten male SD rats were randomly allocated into morphine group (intraperitoneally injected morphine twice a day for 10 d in ascending dosage schedule) or control group (injected normal saline of the same volume). Rats were killed on the 6th d following the last injection. NAc and HIPCA1 were removed and prepared. The ultrastructures of neurons in NAc and HIPCA1, including membrane of nucleus, mitochondria, endoplasmic reticulum were investigated under transmission electron microscope. Results: Compared with control, the neurons in NAc of morphine GA treated rats had the blurred nuclear membrane and mitochondria,and slightly dilated endoplasmic reticulum, while the neurons in HIPCA1 had the blurred membrane of nucleus and mitochondria, vanished matrix and even vacuole degeneration of mitochondria. Conclusion: Chronic morphine treatment may cause the damage of ultrastructure of neurons in NAc and HIPCA1 of rats.