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2007•Zhongguo shiyong neike zazhiRequires access

Study on the blood levels of CD4~+ CD28~-T cells and TNF-α in patients with acute cerebral infarction

Feng Jua

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Abstract

Objective To investigate the roles of CD4+ CD28-T subset and TNF-α in patients with cerebral infarction(CI).Methods The blood levels of CD4+ CD28-T cells and TNF-α in patients and normal controls were studied by immunophenotyping and flow cytometry analysis as well as by ELISA.Results The percentages of CD4+ CD28-T subset in blood(P0.01)and the serum levels of TNF-α(r=0.51,P0.05)in patients were significantly higher than in normal controls.There was a positive correlation between the percentages of CD4+ CD28-T subset and the serum levels of TNF-α(r=0.51,P0.05).Conclusion The levels of both CD4+ CD28-T cells and TNF-α were increased markedly and had a positive correlation in this study.Interaction between TNF-α and CD4+ CD28-T cells might play an important role in cerebral infarction.

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What this paper is about

Objective To investigate the roles of CD4+ CD28-T subset and TNF-α in patients with cerebral infarction(CI).Methods The blood levels of CD4+ CD28-T cells and TNF-α in patients and normal controls were studied by immunophenotyping and flow cytometry analysis as well as by ELISA.Results The percentages of CD4+ CD28-T subset in blood(P0.01)and the serum levels of TNF-α(r=0.51,P0.05)in patients were significantly higher than in normal controls.There was a positive correlation between the percentages of CD4+ CD28-T subset and the serum levels of TNF-α(r=0.51,P0.05).Conclusion The levels of both CD4+ CD28-T cells and TNF-α were increased markedly and had a positive correlation in this study.Interaction between TNF-α and CD4+ CD28-T cells might play an important role in cerebral infarction.

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Available abstract

Objective To investigate the roles of CD4+ CD28-T subset and TNF-α in patients with cerebral infarction(CI).Methods The blood levels of CD4+ CD28-T cells and TNF-α in patients and normal controls were studied by immunophenotyping and flow cytometry analysis as well as by ELISA.Results The percentages of CD4+ CD28-T subset in blood(P0.01)and the serum levels of TNF-α(r=0.51,P0.05)in patients were significantly higher than in normal controls.There was a positive correlation between the percentages of CD4+ CD28-T subset and the serum levels of TNF-α(r=0.51,P0.05).Conclusion The levels of both CD4+ CD28-T cells and TNF-α were increased markedly and had a positive correlation in this study.Interaction between TNF-α and CD4+ CD28-T cells might play an important role in cerebral infarction.

Key concepts: Medicine, CD28, Tumor necrosis factor alpha, Immunophenotyping, Flow cytometry, Internal medicine, Immunology, Endocrinology

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Study on the blood levels of CD4~+ CD28~-T cells and TNF-α in patients with acute cerebral infarction — Research Paper | ScholarLens