2009•Unpublished venueRequires access
Association in expression of Galectin-1,PR and the peritoneal metastasis in gastric cancer
Qing Du-ju
Open publisher page 0 citations
Abstract
Objective:To investigate the expression of galectin-1 and progesterone receptor in gastric cancer with peritoneal metastasis.Methods:The expression of galectin-1 and progesterone receptor were detected in matching-samples including gastric cancer lesions,lymph node metastases,peritoneal metastasis and paratumor normal tissues by immunohistochemistry.All specimens were gained from 40 gastric cancer patients who had synchronous peritoneal metastasis.Results:The expressions of galectin-1 and progesterone receptor were higher in gastric cancer lesions,the peritoneal metastasis and the lymph node metastases than those in paratumor normal tissues.There were significant differences in expression of galectin-1 and progesterone receptor between paratumor normal tissues and gastric carcinoma lesions,peritoneal metastasis,lymph node metastases respectively(P0.05),but there were no significant differences among the gastric carcinoma lesions,peritoneal metastasis and lymph node metastases(P0.05).Conclusion:The expression of galectin-1 and progesterone receptor in gastric cancer lesions can be used as a biological marker of peritoneal metastasis from gastric cancer before operation and as a prognostic factor of gastric cancer.