Serum levels and clinical significance of IL-6,IL-1β,TNF-α and CRP in patients with depressive disorder

Objective To study the changes of serum levels of IL-6,IL-1β,TNF-α and C-reactive protein (CRP) in patients with depressive disorder. Methods Forty six patients with depressive disorder (depressive group) and 35 healthy subjects (control group) were recruited for the research. The serum levels of IL-6,IL-1β,TNF-α were determined by enzyme-linked immunosorbent assay (ELISA) and CRP were determined by scatter velocity turbidimetry. Results The serum levels of IL-6,TNF-α ,and CRP were (9.03±5.38)pg/ml,(14.11±7.48)pg/ml,and (6.73±5.80)mg/L in patients with depressive disorder,which were significantly higher than that of healthy subjects (t=3.12,2.45,2.88,P0.05). There was no significant difference in the serum level of IL-1β between two groups. The serum level of IL-6 was significantly correlated with TNF-α (r=0.48,P0.05) in patients with depressive disorder. Conclusions The high serum levels of IL-6,TNF-α,and CRP may be related with the process of depressive disorder.