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2015•Hang'gong uihagRequires access

Analysis of Prognostic Factors of Affecting Intrahepatic Cholangiocarcinoma

Chang Jinzh

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Abstract

Objective To explore the prognostic factors of intrahepatic cholangiocarcinoma( ICC) undergoing hepatectomy. Methods Clinical data of 98 patients with pathologically confirmed ICC treated at cancer center,fromjanuary2001 to December 2011 were reviewed. Survival and prognosis were analyzed by Kaplan-meier method and cox regression model. Results The 1-,3-and 5-year survival rates of the 98 apatients were 54. 07%,32. 40% and 19. 82%,respectively. The univariate statistical analysis showed that serum level of AFP,CA199,CEA,TB and AST affected postoperative survival; whereas multivariate analysis found that serum level of CA199,CEA and TB wrer the independent prognostic factor. Conclusions Radical resection is the main effective treatment for ICC patoents to achieve long-term survival. Preoperative serum levels of CA199,CEA and TB are significant prognostic factor for patients with respectable ICC.

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What this paper is about

Objective To explore the prognostic factors of intrahepatic cholangiocarcinoma( ICC) undergoing hepatectomy. Methods Clinical data of 98 patients with pathologically confirmed ICC treated at cancer center,fromjanuary2001 to December 2011 were reviewed. Survival and prognosis were analyzed by Kaplan-meier method and cox regression model. Results The 1-,3-and 5-year survival rates of the 98 apatients were 54. 07%,32. 40% and 19. 82%,respectively. The univariate statistical analysis showed that serum level of AFP,CA199,CEA,TB and AST affected postoperative survival; whereas multivariate analysis found that serum level of CA199,CEA and TB wrer the independent prognostic factor. Conclusions Radical resection is the main effective treatment for ICC patoents to achieve long-term survival. Preoperative serum levels of CA199,CEA and TB are significant prognostic factor for patients with respectable ICC.

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Available abstract

Objective To explore the prognostic factors of intrahepatic cholangiocarcinoma( ICC) undergoing hepatectomy. Methods Clinical data of 98 patients with pathologically confirmed ICC treated at cancer center,fromjanuary2001 to December 2011 were reviewed. Survival and prognosis were analyzed by Kaplan-meier method and cox regression model. Results The 1-,3-and 5-year survival rates of the 98 apatients were 54. 07%,32. 40% and 19. 82%,respectively. The univariate statistical analysis showed that serum level of AFP,CA199,CEA,TB and AST affected postoperative survival; whereas multivariate analysis found that serum level of CA199,CEA and TB wrer the independent prognostic factor. Conclusions Radical resection is the main effective treatment for ICC patoents to achieve long-term survival. Preoperative serum levels of CA199,CEA and TB are significant prognostic factor for patients with respectable ICC.

Key concepts: Medicine, Intrahepatic Cholangiocarcinoma, Internal medicine, Multivariate analysis, Univariate analysis, Proportional hazards model, Gastroenterology, Hepatectomy

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