Clinical pathological features of triple-negative breast cancer and HER-2 overexpression breast cancer.

Objective To investigate the clinical pathological features of triple-negative breast cancer and HER-2 overexpression breast cancer. Methods A total of 210 patients with breast cancer of negative expression of estrogen and progesterone receptorses were selected as the research objects, which were divided into two groups according to the results of HER-2 detection: triple-negative breast cancer group(with negative expression of ER, PR and HER-2, n=85), HER-2 overexpression breast cancer group(with negative expression of ER, PR and positive expression of HER-2, n=125). The lesion site, pathological type, tumor size, lymph node metastasis, histological grade, TMN stage, P53 expression and Ki-67 expression of two groups were analyzed. Results There was no significant difference in lesion site between triple-negative breast cancer group and HER-2 overexpression breast cancer group(P=0.4317), and the upper outer quadrant area occupied the highest ratio, about 58.82% and 46.4%. There was no significant difference in pathological types, tumor size, TMN staging, and P53 expression between triple-negative breast cancer group and HER-2 overexpression breast cancer group(P=0.6146, P=0.2744, P=0.5909, P=0.6002), and the invasive ductal carcinoma, the tumor size(2~5 cm), and stage Ⅱ occupied the highest ratio. Lymph node metastasis with positive in triple-negative breast cancer group accounted for 56.47%, and lymph node metastasis with negative in HER-2 overexpression breast cancer group accounted for 67.2%. The differences was statically significant(χ2=11.609, P=0.0007). The differences was statically significant in histological grade(P=0.0278), and histological gradeⅡ occupied the highest ratio. The differences was statically significant in Ki-67 expression between triple-negative breast cancer group and HER-2 overexpression breast cancer group(P=0.0041). Conclusion Triple-negative breast cancer and HER-2 overexpression breast cancer often occur in the upper outer quadrant area, and are mainly in invasive ductal carcinoma, and stage II. Triple-negative breast cancer is stronger in invasion, higher in histological grade, more apt to lymph node metastasis, and has a poorer prognosis than HER-2 overexpression in breast cancer.