Correlation of subclinical hypothyroidism with chronic kidney disease in patients with type 2 diabetes

Objective To explore the relationship between subclinical hypothyroidism and chronic kidney disease in patients with type2 diabetes.Methods The clinical data were respectively analyzed in 991 patients with type 2 diabetes at admission from Second Affiliated Hospital of Chongqing Medical University from January 2012 to January 2013.Patients with normal levels of free triiodothyronine and free thyroxine,but an increased level of thyroid stimulating hormone( TSH)( 5.00 m U / L),were diagnosed with subclinical hypothyroidism.The prevalence of chronic kidney disease was observed and compared between euthyroidism and subclinical hypothyroidism.Logistic regression analysis was used to analyze the relationship between subclinical hypothyroidism and chronic kidney disease.Results Of 991 patients,126( 12.7%) had subclinical hypothyroidism.Patients with subclinical hypothyroidism had no significant difference from euthyroid patients with regard to prevalence of chronic kidney disease( P 0.05).The prevalence of chronic kidney disease was significantly higher in patients with TSH≥10 m U / L than in patients with lower TSH of 0.35-0.99 m U / L( P 0.05).The logistic regression analysis showed that the severe SCH was a high risk factor for CKD( OR 1.842,95% CI 1.120-3.029,P = 0.016).Conclusion In type 2 diabetic patients,the incidence of chronic kidney disease is higher in patients with severe subclinical hypothyroidism than those in mild subclinical hypothyroidism and euthyroidism.