Pharmacokinetics of Ciprofloxacin Following Intravenous and Oral Administration in Broiler Chickens

Sixteen broiler chickens were divided into two groups by intravenous and oral administration.Plasma concentrations of ciprofloxacin were determined by HPLC method after intravenous and orally administered doses of 10 mg/kg of body weight.The concentration-time data of ciprofloxacin in plasma were analyzed with MCPKP program.The results showed that the concentration-time data of ciprofloxacin in plasma after intravenous administration in healthy broiler chickens are fitted to a two-compartment open model.The main pharmacokinetic parameters are as follows:t 1/2α,(0.234±0.049) h;t 1/2β,(10.118±0.271) h,V B,(1.374±0.124) L/kg,CL B,(0.094±0.009) L·kg -1·h -1,AUC,(107.068±10.640) mg·L -1·h?A one-compartment open model describes the concentrations-time data of ciprofloxacin in plasma following oral administration in healthy broiler chickens.The main pharmacokinetic parameters are as follows:t 1/2kα,(0.114±0.008) h;t 1/2k,(7.784±0.514) h,T p,(0.702±0.031) h,C max,(5.736±0.515) mg/L;AUC,(68.622±8.147) mg·L -1·h;F,(64.092±7.610)%.After intravenous administration of ciprofloxacin in broiler chickens,elimination was slow and distribution in body was wide.After oral administration of ciprofloxacin,absorption was very speed and elimination was faster than intravenous administration.