2007•Acta Academiae Medicinae CpapfRequires access
Study on the activity of phosphatases and the calcium dependence of calcineurin in different tissues of rat
Gongyuan Yu
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Abstract
【Objective】 To observe the activity and distribution of phosphatases and the calcium dependence of calcineurin in different tissues of rat.【Method】 The activity of calcineurin and other phosphatases in different tissues,and the activity of calcineurin in different calcium with uv-spectrophotometer.【Results】The activity of calcineurin in brain was higher than that in other tissues(6.81±2.41,P0.01).The activity of phosphatases in brain was higher than that in other tissues(7.59±1.93,P0.01).The activity of PP2C in brain is higher than that in other tissues(4.55±1.72,P0.01).As the concentration of calcium was added,the activity of calcineurin was increased.When pCa increased to 4.52,however,the activity of calcineurin was decreased.【Conclusion】These results suggest that the activity of phosphatases in brain are higher than in other tissues,and the result of calcium dependence presents a change of a bell shape.