2006•PubMedRequires access

Molecular study of genes involved in virulence regulatory pathways in Bacillus anthracis vaccine strain "Carbosap".

Giuseppina La Rosa, Michele Muscillo, Michela Sali, Elena De Carolis, Cinzia Marianelli, F. Ciuchini, Antonio Fasanella, Rosanna Adone

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Abstract

This study investigated the genetic bases of attenuation in the Bacillus anthracis vaccine strain "Carbosap" used in Italy against anthrax in cattle and sheep. Twelve genes involved in virulence regulatory pathways underwent sequence analysis in comparison with a B. anthracis virulent strain.

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Key concepts: Bacillus anthracis, Virulence, Anthrax vaccines, Strain (injury), Biology, Microbiology, Gene, Attenuated vaccine