Antifungal activity of ethanol extract from Coreopsis grandiflora.

The antifungal activities of Coreopsis grandiflora ethanolic extract and fractions were determined against 10 kinds of fungi.The antifungal activity of C.grandiflora was determined by using growth rate method.The results showed that the ethanol extract from C.grandiflora had a significant inhibitory activities against Gibberella zeae,Alternaria alternata f.sp.mali,Colletotrichum capsici and Fusarium oxysporum f.sp.cucumerinum,and the inhibition rates were 48.45%,31.94%,23.22% and 22.69% at 2.0 mg·mL-1,respectively,and the EC50 of ethanolic extract to A.alternate and G.zeae were 2.872 mg·mL-1 and 1.570 mg·mL-1.The antifungal activities of n-hexane,ethyl acetate,n-butanol and water partition from ethanol extracts showed that the highest activity components were distributed in n-hexane extracts and water partition.The EC50 of n-hexane partition to A.alternate and G.zeae were 1.111 and 0.194 mg·mL-1,and the EC50 of water partition were 1.878 and 1.390 mg·mL-1.