The relationship between the change of the Th Cytokine and the pregnancy-induced hypertension

Objective To study the difference of cytokine between the normal pregnancy and pregnancy induced hypertension(PIH). Methods Peripheric blood and sera were obtained of 20 normal pregnancy and 50 PIH who were divided into three groups(mild, moderate and severe).Cytokine of tumor necrosis factor-alpha (TNF-α)、interleukin-2(IL-2)、of interleukin-6(IL-6) were determined by using enzyme-linked immunosorbent assay (ELISA). Results The serum concentrations of TNF-αwere significantly higher in the group of PIH compared with the control group (P0.05). The serum concentrations of IL-2 were significantly higher in the moderate and severe group of PIH compared with the control group(P0.05). The serum concentrations IL-6 were significantly higher in the severe group of PIH compared with the control group (P0.05). The ratios of TNF/IL-6 and IL-2/IL-6 did not have significant differences between the control group and the PIH group(P0.05). Conclusion Cytokines of TNF-α、IL-2、IL-6 may be relevant in the pathogenesis of PIH.