Survival analysis of non-small cell lung cancer patients with brain metastases by Cox regression

Objective To evaluate the prognosis factors for non-small cell lung cancer patients with brain metastases. Methods The clinical data of 302 patients of non-small cell lung cancer patients with brain metastases were reviewed,and only 171 cases with adequate survival data were analyzed respectively. The clinical factors and treatment procedures were analyzed by univariate analysis and Cox regression to evaluate the effect on prognosis. Results The overall median survival time for this group patients was 8. 8( 95% CI: 7. 2 ~ 10. 3) months. The univariate analysis demonstrated the PS score( P = 0. 002),number of brain metastasis( P = 0. 023),time of brain metastases( P = 0. 031),radiotherapy methods( P = 0. 041) and tumor resection in lung( P = 0. 002) were associated with the prognosis. In the Cox regression analysis,the PS score( P = 0. 04) and lung surgery( P = 0. 04) were independent prognosis factors for NSCLC patients with brain metastases,but they had no relationship with number of brain metastasis( P = 0. 65),time of brain metastases( P = 0. 71) and radiotherapy methods( P = 0. 91). Conclusion The general prognosis of NSCLC patients with brain metastases is poor. Patients with lung carcinoma resection and good quality of physical activity may have a superior prognosis.