Comparison of different methods in detection of neonatal bilirubin

Objective:To explore the differences of neonatal bilirubin detection with different methods,find a good method to monitor the dynamic changes of neonatal bilirubin. Methods:Three methods including automatic biochemical analyzer(biochemical method),trace bilirubin analyzer(micromethod) and percutaneous bilirubin meter(percutaneous method) were used to detect the bilirubin levels of 90 neonates,then the differences were compared;micromethod and percutaneous method both were used to monitor the bilirubin levels of 392 normal full-term neonates at 1~7 days after birth dynamically,then the difference was compared. Results:There was no significant difference in measured value of bilirubin between micromethod and biochemical method(P 0.05);when the level of bilirubin was less than 200 μmol/L and within 201~300 μmol/L,there was no significant difference in measured value of bilirubin between percutaneous method and biochemical method(P0.05);when the level of bilirubin was more than 300 μmol/L,there was significant difference in measured value of bilirubin between percutaneous method and biochemical method(P0.05);there was significant difference in measured value of bilirubin in neonates at 1~7 days after birth between micromethod and percutaneous method(P0.05). Conclusion:Micromethod is accurate and easy to operate in detection of neonatal bilirubin,which is superior to biochemical method and percutaneous method in dynamic monitoring of neonatal bilirubin.