ScholarLens Back to search
2007•Journal of environmental healthRequires access

Toxic Effects of Rotenone on Substantia Nigra of Rats

Zhaoju Dong

Open publisher page 0 citations

Abstract

Objective To study the toxic effects of rotenone on substantia nigra of rats. Methods Rotenone was given subcutaneously once a day during 28 days. Substantia nigra was dissected. Morphology of dopamine neuron, synapse and myelin sheath were observed. SOD and GSH-Px activity were assayed; MDA and GSH contents were measured. Results Autonomic activities of rats decreased, similar to Parkinson's Symptoms. Morphology of dopamine neuron changed, synapse structures were abnormal, synapse vesicals increased and myelin sheath degenerated. MDA content increased (P0.01) and GSH content decreased(P0.01). SOD and GSH-Px activity declined(P0.01). Conclusion Dopamine neuron is damaged and symptoms asimilar to Parkinson's Diseases of rats are induced by rotentone. Oxidative stress is involved in the toxic effects of rats treated with rotenone.

About this research paper

What this paper is about

Objective To study the toxic effects of rotenone on substantia nigra of rats. Methods Rotenone was given subcutaneously once a day during 28 days. Substantia nigra was dissected. Morphology of dopamine neuron, synapse and myelin sheath were observed. SOD and GSH-Px activity were assayed; MDA and GSH contents were measured. Results Autonomic activities of rats decreased, similar to Parkinson's Symptoms. Morphology of dopamine neuron changed, synapse structures were abnormal, synapse vesicals increased and myelin sheath degenerated. MDA content increased (P0.01) and GSH content decreased(P0.01). SOD and GSH-Px activity declined(P0.01). Conclusion Dopamine neuron is damaged and symptoms asimilar to Parkinson's Diseases of rats are induced by rotentone. Oxidative stress is involved in the toxic effects of rats treated with rotenone.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the toxic effects of rotenone on substantia nigra of rats. Methods Rotenone was given subcutaneously once a day during 28 days. Substantia nigra was dissected. Morphology of dopamine neuron, synapse and myelin sheath were observed. SOD and GSH-Px activity were assayed; MDA and GSH contents were measured. Results Autonomic activities of rats decreased, similar to Parkinson's Symptoms. Morphology of dopamine neuron changed, synapse structures were abnormal, synapse vesicals increased and myelin sheath degenerated. MDA content increased (P0.01) and GSH content decreased(P0.01). SOD and GSH-Px activity declined(P0.01). Conclusion Dopamine neuron is damaged and symptoms asimilar to Parkinson's Diseases of rats are induced by rotentone. Oxidative stress is involved in the toxic effects of rats treated with rotenone.

Key concepts: Rotenone, Substantia nigra, Dopamine, Neuron, Oxidative stress, Glutathione, Synapse, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Toxic Effects of Rotenone on Substantia Nigra of Rats — Research Paper | ScholarLens