2010•Beijing Journal of StomatologyRequires access

CD44 expression in oral squamous cell carcinoma

Xing Ru-don

Abstract

Objective To examine the expression of CD44 in oral squamous cell carcinoma.Methods Samples of 22 oral SCC and their neighboring incised mucosa were collected and immunohistochemically stained for the expression of CD44.CD44 expression in lesions with different differentiation was compared and analyzed.Results CD44 was expressed in basal and some prickle layer cells of normal mucosa and strongly expressed in lymphocytes as well.The expression of CD44 varied with different differentiation of the SCC tissues,presenting down-regulation in the poor differentiated tissues.Conclusion CD44 could be used as one of the markers for the malignant degree of the oral squamous cell carcinoma.

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Key concepts: CD44, Basal cell, Pathology, Immunohistochemistry, Oral mucosa, Basal (medicine), Cell, Carcinoma