Comparison of Efficacy of Thrombolytic Therapy versus Anticoagulant Therapy in Treatment of Pulmonary Thromboembolism

Objective To compare the clinical efficacy of thrombolytic therapy with Urokinase versus anticoagulant therapy with low-molecular-heparin in the treatment of pulmonary embolism(PE).Methods Clinical data of 48 patients with PE were retrospectively analyzed.Results Heart rate and breathing rate of the thrombolysis group and anticoagulation group decreased significantly after therapy.PaO2 and PaCO2 decreased significantly as well,but the anticoagulation group was less marked than the thrombolysis group(P0.05).The total effective rates of the thrombolysis group and anticoagulation group were respectively 96.2% and 88.5%,total effectiveness of the two groups compared,having a significant difference(P0.05).Conclusion The therapeutic efficacy of thrombolytic therapy with Urokinase is higher than that of anticoagulant therapy with low-molecular-heparin in the treatment of pulmonary embolism.