Study on reminiscent responsion of Hepatitis B vaccine booster immunization in 3～12 years-old children of Beijing

Objective To evaluate the character of the reminiscent responsion of the Hepatitis B vaccmebooster immunization on the children who were anti-HBs negative in Beijing.Methods The multiple stratified cluster sampling was used in this epidemiological survey.The sampling children's blood serum HBsAg,anti-HBs and anti-HBc were checked and measured by the Solid Phase Radioimmunoassay(SPRIA).The children whose anti-HBs serological titer(GMT)was lower than 10?Iu/L had the Hepatitis B vaccine booster immunization in two different dosages.Results 2?419 3～12 years-old children who were immunized by the Hepatitis B vaccine in the infant period were surveyed and the total anti-HBs negative rate was 48.25%(CI%,35.15～64.26).725 children had the Hepatitis B vaccine booster immunization and the anti-HBs positive rate was observed.The anti-HBs positive rate of the children who were immunized in 2.5?μg and 5.0?μg Hepatitis B vaccine was 90.6% and 90.9% respectively.The GMT was 85.69 and 87.59?Iu/L respectively.The anti-HBs positive rate was also analyzed according to the different time of the blood sampling.And there were both no statistical significances between the two dosages(χ~2=0.02,P=0.89;t=0.36,P=0.72).The average anti-HBs positive rate was 92.80% and the GMT was 84.55?Iu/L after 4～5 weeks.The average anti-HBs positive rate was 86.66%and the GMT was 91.39?Iu/L after 6～22 weeks.There were statistical significance for the average anti-HBs positive rate(χ~2=7.47,P=0.006) and no statistical significance for the anti-HBs GMT between the different blood samplmg time(t=1.09,p=0.28).Conclusion For the 3～12 years-old children who had finished the basic immunization of Hepatitis B vaccine in the infant period,a little dose of Hepatitis B vaccine could make responsion strongly in their bodies after the antibody died away.It showed that there was remimscent responsion for the Hepatitis B virus in their bodies.This reminiscent responsion could be the main cause that made people have the long-term protection of Hepatitis B vaccine.