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2004•Chinese Clinical OncologyRequires access

Oxaliplatin in combination with leucovorin and 5-fluorouracil for advanced colorectal cancer

Leilei Yuan

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Abstract

Objective:To evaluate the effects and safety of oxaliplatin in combination with leucovorin and 5-fluorouracil regimen for patients with advanced colorectal cancer.Methods:OXA 130mg/m2 iv 4h d1,CF 200mg iv 2h followed by 5-Fu 0.25 iv plus 5-Fu 0.5 continuous infusion 6～8 hours,d1～5.Results:The overall response rate(CR+PR)was 42.31%.The main side effects were mild neuro-sensory toxicity,suppression of bone marrow,nausea and vomiting of grade Ⅰ to Ⅱ.Conclusion:OXA in combination with leucovorin and 5-fluorouracil is a high response regimen for advanced colorectal cancer with mild toxicity,which can be practiced safely.

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What this paper is about

Objective:To evaluate the effects and safety of oxaliplatin in combination with leucovorin and 5-fluorouracil regimen for patients with advanced colorectal cancer.Methods:OXA 130mg/m2 iv 4h d1,CF 200mg iv 2h followed by 5-Fu 0.25 iv plus 5-Fu 0.5 continuous infusion 6～8 hours,d1～5.Results:The overall response rate(CR+PR)was 42.31%.The main side effects were mild neuro-sensory toxicity,suppression of bone marrow,nausea and vomiting of grade Ⅰ to Ⅱ.Conclusion:OXA in combination with leucovorin and 5-fluorouracil is a high response regimen for advanced colorectal cancer with mild toxicity,which can be practiced safely.

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Available abstract

Objective:To evaluate the effects and safety of oxaliplatin in combination with leucovorin and 5-fluorouracil regimen for patients with advanced colorectal cancer.Methods:OXA 130mg/m2 iv 4h d1,CF 200mg iv 2h followed by 5-Fu 0.25 iv plus 5-Fu 0.5 continuous infusion 6～8 hours,d1～5.Results:The overall response rate(CR+PR)was 42.31%.The main side effects were mild neuro-sensory toxicity,suppression of bone marrow,nausea and vomiting of grade Ⅰ to Ⅱ.Conclusion:OXA in combination with leucovorin and 5-fluorouracil is a high response regimen for advanced colorectal cancer with mild toxicity,which can be practiced safely.

Key concepts: Oxaliplatin, Medicine, Fluorouracil, Regimen, Nausea, Vomiting, Bone marrow suppression, Colorectal cancer

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Oxaliplatin in combination with leucovorin and 5-fluorouracil for advanced colorectal cancer — Research Paper | ScholarLens