Geographical distribution of MTHFR C677T,A1298C and MTRR A66G gene polymorphisms among the Han gestational age women in Zhangjiakou city

Objective:To explore the genotype distribution of methylenetetrahydrofolate reductase(MTHFR)C677T,A1298 C and methionine synthase reductase(MTRR)A66G involved in the folic acid biosynthetic pathway among Chinese Han gestational age women in Zhangjiakou. Methods:860 samples were recruited from Zhangjiakou region in He Bei province. Buccal samples were collected and genomic DNA was isolated. The detections of MTHFR and MTRR gene polymorphisms conducted with Taqman-MGB technology. The distribution of gene polymorphisms of this study was analyzed and compared with partial regions of China,which were reported. Results:Among the Han gestational age women in Zhangjiakou,the frequency of MTHFR 677 TT genotype was 31.7%,it was lower than that in Zibo(all P0.01),and higher than that in Zhenjiang Songzi Deyang Huizhou and Qionghai(all P0.01);The frequency of MTHFR 1298 CC genotype was 2.3%,it was higher than that in Zibo,and lower than that in Zhenjiang Songzi Deyang Huizhou and Qionghai(all P0.01);The frequency of MTRR 66 GG genotype was 7.7%,it is significantly different with that in Zibo and Qionghai(P0.05).Conclusion:This study suggests that the gene polymorphism of MTHFR C677 T,A1298C and MTRR A66 G among the Han women in Zhangjiakou was statistically different from partial other regions of China.