Effect of Changningfang in treating diarrhea-predominant irritable bowel syndrome

Objective To observe the clinical effect of Changningfang in treating diarrhea-predominant irritable bowel syndrome(D-IBS).Methods 75 patients with D-IBS treated with Changningfang from July 2008 to December 2012 in Guilin TCM Hospital were reviewed.Patients were randomized divided into 38 cases of treatment group and 37 cases of control group.The patients in treatment group were treated with Changningfang,the patients in control group were treated with Pinaverium.Before treatment and after treatment for 3 weeks,the clinical symptoms,symptom scores and the level of 5-hydroxytryptamine serotonin(5-HT),motilin(MOT) in serum were compared.Results The total efficiency and cure rate of syndrome of treatment group(47.4%,92.1%) were better than those of the control group(24.3%,81.1%),there were significant differences between the two groups(P 0.05);the symptom scores of treatment group [(8.52±3.43) points] were better than that of the control group [(13.01±2.50) points],there were significant differences between two groups(P 0.01).The effect of the spleen dampness syndrome type and the stagnation and spleen deficien cy syndrome type in the treatment group(both 100.0%) were better than the control group(77.8%,90.0%),there were significant differences between two groups(P 0.01 or P 0.05);the level of 5-HT,MOT in the treatment group were(433.4±72.6) ng/L,(240.1±11.8) ng/L,which were less than those of control group [(433.4±72.6) ng/L,(314.1±60.7) ng/L],there were significant differences between the two groups(P 0.01).Conclusion Changningfang can significantly improve the D-IBS patients with clinical symptoms,its mechanism of action may be related to the regulation of 5-HT,MOT level.