Clinical Observation of Different Doses of Bupivacaine Subarachnoid Anesthesia for Cesarean Section

OBJECTIVE: To investigate the optimal dose of bupivacaine subarachnoid anesthesia for cesarean section. METHODS: 180 patients undergoing elective cesarean section were randomly divided into 3 groups. They were given 0.75% bupivacaine 2.0 mL (group A of 60 patients), 1.5 mL (group B of 60 cases), 1.2 mL (group C of 60 cases), for spinal anesthesia. The onset time of anesthesia, pain disappearance time, pain recovery time, motor block recovery times, the maximum degree of motor block, 5, 10, 15, 30 min before and after anesthesia, blood pressure, heart rate, oxygen saturation (SpO2), Apgar score, the occurrence of anesthesia hypotension, nausea, vomiting, headache and other maternal adverse events were all observed. RESULTS: The anesthetic onset time and pain recovery time of 3 groups showed no significant difference (P0.05), and pain disappearance time, Bromage scores and motor block recovery times had significant difference among group A, B and C (P0.05). The heart rate and SpO2 before anesthesia and 5, 10, 15, 30 min after anesthesia had no significant difference among 3 groups (P0.05); blood pressure of group A after 5 min anesthesia decreased, there was significant differences between group B and C (P0.05), blood pressure of 3 groups showed no significant difference at other times (P0.05). Apgar scores of 3 groups were 7 points 1, 5, 10 min after birth, there was no significant difference (P0.05). Intra-operative hypotension and nausea in group A had a high incidence, ther was significantly difference between group A and group B, C (P0.05). Intra-operative vomiting and postoperative headache had no significant difference among 3 groups (P0.05). CONCLUSION: 1.5 mL 0.75% bupivacaine subarachnoid anesthesia for cesarean section is effective, both to ensure the anesthetic effect, but also to minimize side effects.