Prognostic effects of delayed percutaneous coronary intervention at different time windows on patients with acute ST-segment elevation myocardial infarction

Objectives To compare the prognostic effects of different time windows on delayed percutaneous coronary intervention(PCI) on patients with acute ST-elevation myocardial infarction(STEMI). Methods Totally 109 patients with ST-segment elevation myocardial infarction(STEMI) in The First Affiliated Hospital of Guangdong College of Pharmacy were enrolled continuously from January 2010 to January 2013. According to the timing of delayed PCI, the patients were divided into 2 groups: group A(timing at 12-24 h, drug therapy after PCI, n=55), group B(timing at 5-14 d, PCI after drug therapy,n=54). Left ventricular end-systolic volume index(LVESVI), left ventricular end-diastolic volume index(LVEDVI) and left ventricular ejection fraction(LVEF) were determined by echocardiogram within 72 hours,1 month and 1 year after admission. Left cardiac function was evaluated. Occurrence of major adverse cardiovascular events(MACE) in the two groups was compared. Results The basic data and information before and during operation of the two group had no significant difference(P0.05). There was no significant difference in left cardiac function between the two groups at the first 3 d after admission(P0.05). However, 1 month and 1 year after PCI, the left cardiac functions in group A were significantly better than those in group B(P0.05). The incidence of MACE, heart failure and mortality in group A was significantly lower than that in group B(P0.05). Conclusions Delayed PCI at time windows within 24 h can still improve the prognosis of patients with STEMI.