Clinical analysis of interventional cholangiography drainage combined CT guided percutaneous 125I seeds implantation treatment for malignant obstructive jaundice

Objective:To explore the safety and efficacy of interventional cholangiography drainage combined with CT guided percutaneous 125I seeds implantation treatment for malignant obstructive jaundice(MOJ).Methods: Nineteen patients with MOJ were carried out alleviative jaundice by interventional technique,and performed CT guided percutaneous 125I seeds implantation after 4~6 weeks.The clinical efficacy and accumulative survival rate were evaluated after the procedures.Results: Three patients with MOJ were carried out an expandable metallic biliary endoprothesis(EMBE),and the sixteen percutaneous transhepatic cholangiography drainage(PTCD).Eight to sixty(mean 27.1) 125I seeds were implanted into a single tumor at first time.No obvious complication occurred during the procedure.The total clinical efficacy was 47.4%(9/19)with CR 1,and PR 8.The survival rates of 6,12,18,24,30,36 months were 57.9%(11/19),36.8%(7/19),26.3%(5/19),15.8%(3/19),15.8%(3/19) and 0%(0/19)respectively.Conclusion: Interventional cholangiography drainage combined CT guided percutaneous 125I seeds implantation treatment for malignant obstructive jaundice is not only safe,but also definitely effective.